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Publications

Independent Research

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Mentored Research

  1. Kim, A. T.; Howard, J. R.; Cuba Cáceres, A. G.; Chong, K. I.; Aye, W. A.; Sigman, M. S.; Narayan, A. R. H. Catalytically Promiscuous PLP-Dependent Aminotransferases Are Biocatalysts for C–C Bond Formation. ACS Cent. Sci. 2026, 12, 1029–1037. 10.1021/acscentsci.6c00531

  2. Paudel, P.; Ray, I.; Al Danoon, O.; Howard, J. R.; Maier, J. M.; Moor, S. R.; Lidskog, A. M.; Anslyn, E. V.; Mohanty, S. Disrupting Pheromone Signaling in Insects: Design, Synthesis, and Evaluation of an Inhibitor. ACS Omega 2026, 11, 13052–13061. 10.1021/acsomega.5c06376

  3. Deolka, S.; Samha, M. H.; Garcia Roca, A.; Haugh, G. C.; Howard, J. R.; Dalmau, D.; Sandres, J.; Vasylevskyi, S.; VanderLinden, R. T.; Paton, R. S.; Sigman, M. S. Investigating Reactivity and Selectivity in a Palladium-Catalyzed Heteroleptic Ligand System for Electrophilic Arene Fluorination. J. Am. Chem. Soc. 2025, 147, 12878–12889. 10.1021/jacs.5c01738

  4. Shuluk, J. R.; Wight, C. D.; Howard, J. R.; King, M. E.; Moor, S. R.; DeHoog, R. J.; Dahlhauser, S. D.; Eberlin, L. S.; Anslyn, E. V. A Workflow Enabling the Automated Synthesis, Chain-End Degradation, and Rapid Mass Spectrometry Analysis for Molecular Information Storage in Sequence-Defined Oligourethanes. JACS Au 2025, 5, 1232–1242. 10.1021/jacsau.4c01070

  5. Feng, K.†; Raguram, E. R.†; Howard, J. R.; Peters, E.; Liu, C.; Sigman, M. S.; Buchwald, S. L. Development of a Deactivation-Resistant Dialkylbiarylphosphine Ligand for Pd-Catalyzed Arylation of Secondary Amines. J. Am. Chem. Soc. 2024, 146, 26609–26615. 10.1021/jacs.4c09667

  6. Howard, J. R.; Shuluk, J. R.; Bhakare, A.; Anslyn, E. V. Data-Science-Guided Calibration Curve Prediction of an MLCT-Based ee Determination Assay for Chiral Amines. Chem 2024, 10, 2074–2088. 10.1016/j.chempr.2024.05.009

  7. Formen, J. S. S. K.; Howard, J. R.; Anslyn, E. V.; Wolf, C. Circular Dichroism Sensing: Strategies and Applications. Angew. Chem., Int. Ed. 2024, 63, e202400767. 10.1002/anie.202400767

  8. d'Oelsnitz, S.; Diaz, D. J.; Kim, W.; Acosta, D. J.; Dangerfield, T. L.; Schechter, M. W.; Minus, M. B.; Howard, J. R.; Do, H.; Loy, J. M.; Alper, H. S.; Zhang, Y. J.; Ellington, A. D. Biosensor and Machine Learning-Aided Engineering of an Amaryllidaceae Enzyme. Nat. Commun. 2024, 15, 2084. 10.1038/s41467-024-46356-y

  9. Moor, S. R.; Howard, J. R.; Herrera, B. T.; McVeigh, M. S.; Marini, F.; Keatinge-Clay, A. T.; Anslyn, E. V. Determination of Enantiomeric Excess and Diastereomeric Excess via Optical Methods. Application to α-Methyl-β-hydroxy-carboxylic Acids. Org. Chem. Front. 2023, 10, 1386–1392. 10.1039/D2QO01444K

  10. Pierce, J. K.; Hiatt, L. D.; Howard, J. R.; Hu, H.; Qu, F.; Shaughnessy, K. H. Amines as Activating Ligands for Phosphine Palladium(II) Precatalysts: Effect of Amine Ligand Identity on the Catalyst Efficiency. Organometallics 2022, 41, 3861–3871. 10.1021/acs.organomet.2c00518

  11. Valenzuela, S. A.; Howard, J. R.; Park, H. M.; Darbha, S.; Anslyn, E. V. 11B NMR Spectroscopy: Structural Analysis of the Acidity and Reactivity of Phenyl Boronic Acid–Diol Condensations. J. Org. Chem. 2022, 87, 15071–15076. 10.1021/acs.joc.2c01514

  12. Howard, J. R.; Bhakare, A.; Akhtar, Z.; Wolf, C.; Anslyn, E. V. Data-Driven Prediction of Circular Dichroism-Based Calibration Curves for the Rapid Screening of Chiral Primary Amine Enantiomeric Excess Values. J. Am. Chem. Soc. 2022, 144, 17269–17276. 10.1021/jacs.2c08127

  13. Moor, S. R.; Howard, J. R.; Herrera, B. T.; Anslyn, E. V. High-Throughput Screening of α-Chiral-Primary Amines to Determine Yield and Enantiomeric Excess. Tetrahedron 2021, 94, 132315. 10.1016/j.tet.2021.132315

  14. Valenzuela, S. A.; Crory, H. S. N.; Yao, C.-Y.; Howard, J. R.; Saucedo, G.; de Silva, A. P.; Anslyn, E. V. A Colorimetric Method for Quantifying Cis and Trans Alkenes Using an Indicator Displacement Assay. Angew. Chem., Int. Ed. 2021, 60, 13819–13823. 10.1002/anie.202101004

  15. Barnett, K. L.; Howard, J. R.; Treager, C. J.; Shipley, A. T.; Stullich, R. M.; Qu, F.; Gerlach, D. L.; Shaughnessy, K. H. Air-Stable [(R3P)PdCl2]2 Complexes of Neopentylphosphines as Cross-Coupling Precatalysts: Catalytic Application and Mechanism of Catalyst Activation and Deactivation. Organometallics 2018, 37, 1410–1424. 10.1021/acs.organomet.8b00082

† These authors contributed equally.